By using mini-molecules we’ve managed to bridge the obstacles for the activation of TRAIL proteins which enables the organism to fight against tumors like its immunity is completely healthy – says oncologist Wafik El-Deiry from the University in Pennsylvania.
The scientists from the University of Pennsylvania came to a revolutionary discovery which shows that our body is in the condition to overcome cancer by itself. Scientists have isolated a protein called TRAIL which according to their words helps the immunology system to suppress the growth and development of tumors in the organism. Because this protein is a part of the human immunological system, it isn’t poisonous and doesn’t have a negative effect on the health like therapy or radiation.
If the area enclosed with cancer is being treated with TIC10, the TRAIL protein gene is being activated and with a classical therapy against cancer or without it, it helps the immunology system to fight with the malignant cells. What is especially important with this discovery is that the TIC10 molecule is small enough that it can bridge the brain barrier and go into the part of the brain enclosed with tumor directly from the blood, which wasn’t possible until now.
– In the beginning of the research we couldn’t even presume that this molecule could help in the treatment of brain tumors so this is truly a great discovery for us – said the lead researcher, oncologist Wafik El-Deiry from the University in Pennsylvania.
Another positive side of this discovery is that TIC10 doesn’t activate the TRAIL gene only in cancer cells but in the surrounding ones, too which seem healthy at first.
– I am really surprised by what we managed to achieve. By using these mini-molecules we’ve managed to bridge the obstacles for activation of the TRAIL protein which enables the organism to fight against tumors like its immunity is completely healthy – says the scientist.
Considering the fact that they have managed to achieve these discoveries using Guinea pigs, they’ll need several more trials to start applying these TIC10 molecules in human therapies, too.